Myles Brown Selected Research

Lu 28-179 (Siramesine)

1/2020

Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition.

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Myles Brown Research Topics

Disease

109	Neoplasms (Cancer) 05/2022 - 01/2004
82	Breast Neoplasms (Breast Cancer) 01/2021 - 02/2002
55	Prostatic Neoplasms (Prostate Cancer) 05/2022 - 02/2002
10	Carcinogenesis 11/2020 - 09/2004
8	Neoplasm Metastasis (Metastasis) 01/2017 - 09/2009
6	Triple Negative Breast Neoplasms 11/2021 - 04/2014
4	Hypersensitivity (Allergy) 01/2017 - 06/2012
3	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 08/2016
3	Lung Neoplasms (Lung Cancer) 11/2020 - 01/2016
3	Hypoxia (Hypoxemia) 12/2019 - 03/2009
3	Obesity 01/2018 - 06/2015
2	Residual Neoplasm 01/2021 - 01/2021
2	Adenocarcinoma 01/2021 - 11/2020
2	Melanoma (Melanoma, Malignant) 11/2020 - 01/2020
2	Leukemia 11/2016 - 05/2015
2	Disease Progression 09/2011 - 08/2009
2	Osteoporosis 05/2008 - 02/2008
1	Lymphoma (Lymphomas) 01/2022
1	Pathologic Complete Response 01/2021
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2021
1	Aneuploidy (Aneuploid) 11/2020

Drug/Important Bio-Agent (IBA)

43	Androgen Receptors (Androgen Receptor)IBA 05/2022 - 02/2002
37	Estrogen ReceptorsIBA 01/2020 - 01/2004
27	AndrogensIBA 10/2021 - 05/2005
26	Transcription Factors (Transcription Factor)IBA 01/2022 - 08/2006
26	Hormones (Hormone)IBA 01/2021 - 02/2002
25	Estrogens (Estrogen)FDA Link 01/2019 - 06/2005
18	ChromatinIBA 01/2021 - 07/2005
15	Tamoxifen FDA LinkGeneric 01/2019 - 03/2002
14	Biomarkers (Surrogate Marker)IBA 01/2021 - 02/2010
14	Proteins (Proteins, Gene)FDA Link 10/2019 - 05/2008
13	LigandsIBA 10/2021 - 08/2007
13	Estrogen Receptor alphaIBA 10/2019 - 04/2003
8	Pharmaceutical PreparationsIBA 01/2021 - 12/2008
7	Phenobarbital (Luminal)FDA Link 01/2019 - 12/2008
7	Progesterone Receptors (Progesterone Receptor)IBA 01/2018 - 05/2008
6	Immune Checkpoint InhibitorsIBA 01/2022 - 10/2020
6	Biological ProductsIBA 01/2022 - 02/2010
6	RNA (Ribonucleic Acid)IBA 01/2022 - 10/2016
6	Messenger RNA (mRNA)IBA 01/2019 - 09/2004
6	Small Interfering RNA (siRNA)IBA 10/2018 - 06/2009
6	Phosphotransferases (Kinase)IBA 01/2018 - 12/2008
5	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2021 - 12/2006
5	Androgen Antagonists (Antiandrogens)IBA 01/2021 - 04/2009
5	Estradiol (Delestrogen)FDA LinkGeneric 04/2019 - 07/2007
4	Aromatase InhibitorsIBA 01/2019 - 09/2011
4	Histones (Histone)IBA 01/2019 - 01/2017
4	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 12/2008
4	Deoxyribonuclease I (Nickase)IBA 01/2017 - 06/2012
4	Fulvestrant (Faslodex)FDA Link 12/2016 - 09/2011
3	Protein Isoforms (Isoforms)IBA 05/2022 - 06/2013
3	EnzymesIBA 11/2020 - 06/2008
3	Selective Estrogen Receptor Modulators (SERM)IBA 01/2020 - 03/2002
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016 - 10/2010
3	SteroidsIBA 02/2015 - 02/2002
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2011 - 06/2009
2	enzalutamideIBA 05/2022 - 05/2015
2	IntegrinsIBA 11/2021 - 05/2008
2	ChemokinesIBA 10/2021 - 01/2018
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2021 - 01/2020
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2021 - 01/2016
2	InterferonsIBA 10/2020 - 01/2018
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2020 - 01/2011
2	Gonadal Steroid Hormones (Sex Hormones)IBA 04/2019 - 01/2018
2	Letrozole (Femara)FDA LinkGeneric 01/2019 - 01/2017
2	Lysine (L-Lysine)FDA Link 12/2018 - 10/2011
2	Lapatinib (GW572016)FDA Link 03/2018 - 03/2014
2	Cell-Free Nucleic AcidsIBA 01/2018 - 01/2018
2	ORALIT (ORS)IBA 01/2018 - 11/2017
2	Steroid Receptors (Steroid Receptor)IBA 04/2017 - 11/2011
2	Long Noncoding RNAIBA 03/2016 - 07/2013
2	MicroRNAs (MicroRNA)IBA 01/2015 - 08/2009
2	RNA Polymerase II (RNA Polymerase B)IBA 04/2014 - 11/2006
2	Proto-Oncogene Proteins c-etsIBA 03/2013 - 08/2007
2	Nucleosomes (Nucleosome)IBA 06/2012 - 04/2010
2	Cyclin D1IBA 11/2009 - 09/2006
2	IGF Type 1 Receptor (IGF 1 Receptor)IBA 12/2006 - 09/2004
1	CytokinesIBA 01/2022
1	MethyltransferasesIBA 01/2022
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 11/2021
1	Therapeutic UsesIBA 11/2021
1	Chemotactic FactorsIBA 10/2021
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2021
1	birinapantIBA 01/2021
1	Cyclin-Dependent Kinase 9IBA 01/2021
1	SOXB1 Transcription FactorsIBA 01/2021
1	SwainsonineIBA 11/2020
1	Polysaccharides (Glycans)IBA 11/2020
1	palbociclibIBA 11/2020
1	GlucocorticoidsIBA 10/2020
1	Chloroquine (Aralen)FDA LinkGeneric 01/2020
1	LasofoxifeneIBA 01/2020
1	Lu 28-179 (Siramesine)IBA 01/2020
1	Azithromycin (Zithromax)FDA LinkGeneric 01/2020

Therapy/Procedure

58	Therapeutics 01/2022 - 01/2004
17	Castration 01/2022 - 06/2008
5	Immunotherapy 01/2022 - 01/2018
3	Drug Therapy (Chemotherapy) 01/2021 - 10/2012
2	Aftercare (After-Treatment) 01/2021 - 06/2008
1	Prostatectomy (Retropubic Prostatectomy) 01/2021